See the Studies Page for details on the latest real-world safety studies and effectiveness data

Fluzone® High-Dose is a vaccine that helps protect against influenza illness (flu).
Fluzone High-Dose vaccine is for people 65 years of age and older.

At 65+, your risk of flu-related complications is significantly increased. Factors such as lowered immunity and living with chronic health conditions make flu more dangerous than when you were younger.

Fluzone® High-Dose may help reduce your risk of flu and flu-related complications in ages 65+.

Schedule Fluzone High-Dose today.

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Fluzone® High-Dose is the first and only flu shot clinically proven to provide superior flu protection in adults 65+.

In a clinical study conducted in 2011-2012 and 2012-2013 in approximately 32,000 adults 65+, the trivalent formulation of Fluzone® High-Dose proved to be 24% more effective at preventing the flu than standard-dose Fluzone® (Influenza Vaccine).

Compared to Fluzone®, the most common side effects were slightly more frequent and included pain where you got the shot, muscle pain, tiredness, and headache.

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Studied over 12 influenza seasons

The ability of Fluzone High-Dose to protect those 65+ from flu-related hospitalizations, including hospitalizations due to cardiovascular events and respiratory events, was assessed over 12 flu seasons in comparison to regular flu shots.

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The CDC’s Advisory Committee on Immunization Practices (ACIP) selected Fluzone® High-Dose as a preferred vaccine for people 65+ over regular flu shots.†,‡

In August 2023, the CDC’s Advisory Committee on Immunization Practices issued a preferential recommendation for the use of Fluzone® High-Dose over unadjuvanted flu vaccines in adults 65+.

If none of the preferred vaccines are available at an opportunity for vaccine administration, then any other age-appropriate influenza vaccine should be administered.

Fluzone® High-Dose is FREE for almost everyone.§

§The information above is available at CMS.gov and is current as of 5/9/2025. This information is provided for informational purposes only and is not a guarantee of coverage. The information is gathered from various resources and is subject to change.

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for most Medicare
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for most private
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INDICATION

IMPORTANT SAFETY INFORMATION